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1

Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial

Powles, Thomas, Kockx, Mark, Rodriguez-Vida, Alejo, Duran, Ignacio, Crabb, Simon J., Van Der Heijden, Michiel S., Szabados, Bernadett, Pous, Albert Font, Gravis, Gwenaelle, Herranz, Urbano Anido, Prot

Journal:

Nature Medicine

Year:

2019

Language:

english

File:

PDF, 7.82 MB

english, 2019

2

Data Flow Management and Compliance in Cloud Computing

Singh, Jatinder, Powles, Julia, Pasquier, Thomas, Bacon, Jean

Journal:

IEEE Cloud Computing

Year:

2015

Language:

english

File:

PDF, 374 KB

english, 2015

3

Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

Balar, Arjun V, Galsky, Matthew D, Rosenberg, Jonathan E, Powles, Thomas, Petrylak, Daniel P, Bellmunt, Joaquim, Loriot, Yohann, Necchi, Andrea, Hoffman-Censits, Jean, Perez-Gracia, Jose Luis, Dawson,

Journal:

Year:

2017

Language:

english

File:

PDF, 598 KB

english, 2017

4

Immune-Modified Response Evaluation Criteria In Solid Tumors (imRECIST): Refining Guidelines to Assess the Clinical Benefit of Cancer Immunotherapy

Hodi, F. Stephen, Ballinger, Marcus, Lyons, Benjamin, Soria, Jean-Charles, Nishino, Mizuki, Tabernero, Josep, Powles, Thomas, Smith, David, Hoos, Axel, McKenna, Chris, Beyer, Ulrich, Rhee, Ina, Fine,

Journal:

Journal of Clinical Oncology

Year:

2018

Language:

english

File:

PDF, 646 KB

english, 2018

5

Anti ‒ programmed cell death-1/ligand-1 (PD-1/PD-L1) antibodies for the treatment of urothelial carcinoma: state-of-the-art and future development

Powles, Thomas, Necchi, Andrea, Rosen, Galit, Hariharan, Subramanian, Apolo, Andrea B.

Journal:

Clinical Genitourinary Cancer

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

6

What can molecular pathology contribute to the management of renal cell carcinoma?

Stewart, Grant D., O'Mahony, Fiach C., Powles, Thomas, Riddick, Antony C. P., Harrison, David J., Faratian, Dana

Journal:

Nature Reviews Urology (formerly Nature Clinical Practice Urology)

Year:

2011

Language:

english

File:

PDF, 1.20 MB

english, 2011

7

EAU Guidelines on Renal Cell Carcinoma: 2014 Update

Ljungberg, Borje, Bensalah, Karim, Canfield, Steven, Dabestani, Saeed, Hofmann, Fabian, Hora, Milan, Kuczyk, Markus A., Lam, Thomas, Marconi, Lorenzo, Merseburger, Axel S., Mulders, Peter, Powles, Tho

Journal:

European Urology

Year:

2015

Language:

english

File:

PDF, 489 KB

english, 2015

8

Response Rate to Chemotherapy After Immune Checkpoint Inhibition in Metastatic Urothelial Cancer

Szabados, Bernadett, van Dijk, Nick, Tang, Yen Zhi, van der Heijden, Michiel, Wimalasingham, Akhila, Liano, Alfonso Gomez de, Chowdhury, Simon, Hughes, Simon, Rudman, Sarah, Linch, Mark, Powles, Thoma

Journal:

European Urology

Year:

2017

Language:

english

File:

PDF, 768 KB

english, 2017

9

Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial

Rini, Brian I, Powles, Thomas, Atkins, Michael B, Escudier, Bernard, McDermott, David F, Suarez, Cristina, Bracarda, Sergio, Stadler, Walter M, Donskov, Frede, Lee, Jae Lyun, Hawkins, Robert, Ravaud,

Journal:

Lancet (London, England)

Year:

2019

Language:

english

File:

PDF, 646 KB

english, 2019

10

Novel Prognostic Markers in the Serum of Patients With Castration-Resistant Prostate Cancer Derived From Quantitative Analysis of the Pten Conditional Knockout Mouse Proteome

Martin Kälin, Igor Cima, Ralph Schiess, Niklaus Fankhauser, Tom Powles, Peter Wild, Arnoud Templeton, Thomas Cerny, Ruedi Aebersold, Wilhelm Krek, Silke Gillessen

Journal:

European Urology

Year:

2011

Language:

english

File:

PDF, 295 KB

english, 2011

11

Perceived barriers to the development of modern public health in Bulgaria: a qualitative study

Kirstin Woody Scott, John Powles, Hilary Thomas, Boika Rechel

Journal:

International Journal of Public Health

Year:

2011

Language:

english

File:

PDF, 186 KB

english, 2011

12

Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma

Choueiri, Toni K., Escudier, Bernard, Powles, Thomas, Mainwaring, Paul N., Rini, Brian I., Donskov, Frede, Hammers, Hans, Hutson, Thomas E., Lee, Jae-Lyun, Peltola, Katriina, Roth, Bruce J., Bjarnason

Journal:

New England Journal of Medicine

Year:

2015

Language:

english

File:

PDF, 573 KB

english, 2015

13

First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study

Balar, Arjun V, Castellano, Daniel, O'Donnell, Peter H, Grivas, Petros, Vuky, Jacqueline, Powles, Thomas, Plimack, Elizabeth R, Hahn, Noah M, de Wit, Ronald, Pang, Lei, Savage, Mary J, Perini, Rodolfo

Journal:

The Lancet Oncology

Year:

2017

Language:

english

File:

PDF, 299 KB

english, 2017

14

A Randomised Phase 2 Study of AZD2014 Versus Everolimus in Patients with VEGF-Refractory Metastatic Clear Cell Renal Cancer

Powles, Thomas, Wheater, Matthew, Din, Omar, Geldart, Thomas, Boleti, Ekaterini, Stockdale, Andrew, Sundar, Santhanam, Robinson, Angus, Ahmed, Imtiaz, Wimalasingham, Akhila, Burke, Wendy, Sarker, Shah

Journal:

European Urology

Year:

2015

Language:

english

File:

PDF, 359 KB

english, 2015

15

Safety and Efficacy of Pazopanib Therapy Prior to Planned Nephrectomy in Metastatic Clear Cell Renal Cancer

Powles, Thomas, Sarwar, Naveed, Stockdale, Andrew, Sarker, Shah-Jalal, Boleti, Ekaterini, Protheroe, Andrew, Jones, Robert, Chowdhury, Simon, Peters, John, Oades, Grenville, O’Brien, Tim, Sullivan, Ma

Journal:

Year:

2016

Language:

english

File:

PDF, 476 KB

english, 2016

16

Systematic Review of the Role of Cytoreductive Nephrectomy in the Targeted Therapy Era and Beyond: An Individualized Approach to Metastatic Renal Cell Carcinoma

Bhindi, Bimal, Abel, E. Jason, Albiges, Laurence, Bensalah, Karim, Boorjian, Stephen A., Daneshmand, Siamak, Karam, Jose A., Mason, Ross J., Powles, Thomas, Bex, Axel

Journal:

European Urology

Year:

2018

Language:

english

File:

PDF, 1.37 MB

english, 2018

17

Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Immune Checkpoint Inhibition Is the New Backbone in First-line Treatment of Metastatic Clear-cell Renal Cell Carcinoma

Albiges, Laurence, Powles, Tom, Staehler, Michael, Bensalah, Karim, Giles, Rachel H., Hora, Milan, Kuczyk, Markus A., Lam, Thomas B., Ljungberg, Börje, Marconi, Lorenzo, Merseburger, Axel S., Volpe, A

Journal:

European Urology

Year:

2019

Language:

english

File:

PDF, 995 KB

english, 2019

18

Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: A systematic review and meta-analysis of clinical trials in advanced cancer patients

Powles, Thomas, Bracarda, Sergio, Chen, Mei, Norry, Elliot, Compton, Natalie, Heise, Mark, Hutson, Thomas, Harter, Philipp, Carpenter, Christopher, Pandite, Lini, Kaplowitz, Neil

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 492 KB

english, 2015

19

Using a database of protocol studies to evaluate therapy: A breast cancer example

Thomas E. Moon, Stephen E. Jones, Gianni Bonadonna, Trevor J. Powles, Saul Rivkin, Aman Buzdar, Eleanor Montague

Journal:

Statistics in Medicine

Year:

1984

Language:

english

File:

PDF, 397 KB

english, 1984

20

Updated European Association of Urology Guidelines Recommendations for the Treatment of First-line Metastatic Clear Cell Renal Cancer

Powles, Thomas, Albiges, Laurence, Staehler, Michael, Bensalah, Karim, Dabestani, Saeed, Giles, Rachel H., Hofmann, Fabian, Hora, Milan, Kuczyk, Markus A., Lam, Thomas B., Marconi, Lorenzo, Merseburge

Journal:

European Urology

Year:

2017

Language:

english

File:

PDF, 679 KB

english, 2017

21

Preliminary results for avelumab plus axitinib as first-line therapy in patients with advanced clear-cell renal-cell carcinoma (JAVELIN Renal 100): an open-label, dose-finding and dose-expansion, phase 1b trial

Choueiri, Toni K, Larkin, James, Oya, Mototsugu, Thistlethwaite, Fiona, Martignoni, Marcella, Nathan, Paul, Powles, Thomas, McDermott, David, Robbins, Paul B, Chism, David D, Cho, Daniel, Atkins, Mich

Journal:

The Lancet Oncology

Year:

2018

Language:

english

File:

PDF, 1.22 MB

english, 2018

22

Treatment Choices for Front-line Metastatic Clear Cell Renal Cancer

Journal:

European Urology

Year:

2020

Language:

english

File:

PDF, 149 KB

english, 2020

23

A biochemical approach to the staging of human breast cancer

R. C. Coombes, T. J. Powles, J. C. Gazet, H. T. Ford, A. G. Nash, J. P. Sloane, C. J. Hillyard, P. Thomas, J. W. Keyser, D. Marcus, N. Zinberg, W. H. Stimson, A. Munro Neville

Journal:

Year:

1977

Language:

english

File:

PDF, 534 KB

english, 1977

24

Bone metastases in germ cell tumours: lessons learnt from a large retrospective study

Jamal-Hanjani, Mariam, Karpathakis, Anna, Kwan, Amy, Mazhar, Danish, Ansell, Wendy, Shamash, Jonathan, Harper, Peter, Rudman, Sarah, Powles, Thomas, Chowdhury, Simon

Journal:

BJU International

Year:

2013

Language:

english

File:

PDF, 109 KB

english, 2013

25

A phase Ib study investigating the combination of everolimus and dovitinib in vascular endothelial growth factor refractory clear cell renal cancer

Powles, Thomas, Foreshew, Shah-Jalal Sarker, Shamash, Jonathan, Sarwar, Naveed, Crabb, Simon, Sahdev, Anju, Nixon, Jude, Lim, Louise, Pungaliya, Ashish, Foreshaw, Abigail, Davies, Rachel, Greenwood, M

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 566 KB

english, 2014

26

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

Powles, Thomas, Eder, Joseph Paul, Fine, Gregg D., Braiteh, Fadi S., Loriot, Yohann, Cruz, Cristina, Bellmunt, Joaquim, Burris, Howard A., Petrylak, Daniel P., Teng, Siew-leng, Shen, Xiaodong, Boyd, Z

Journal:

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

27

Morphological and immunohistological changes in the skin in allogeneic bone marrow recipients.

Sloane, J P, Thomas, J A, Imrie, S F, Easton, D F, Powles, R L

Journal:

Journal of Clinical Pathology

Year:

1984

Language:

english

File:

PDF, 2.59 MB

english, 1984

28

Development and Use of a Natural History Data Base of Breast Cancer Studies

Moon, Thomas E., Jones, Stephen E., Bonadonna, Gianni, Valagussa, Pinuccia, Powles, Trevor, Buzdar, Aman, Montague, Eleanor

Journal:

American Journal of Clinical Oncology

Year:

1987

File:

PDF, 531 KB

1987

29

Antiangiogenic therapy combined with immune checkpoint blockade in renal cancer

Kuusk, Teele, Albiges, Laurence, Escudier, Bernard, Grivas, Nikolaos, Haanen, John, Powles, Thomas, Bex, Axel

Journal:

Year:

2017

Language:

english

File:

PDF, 714 KB

english, 2017

30

Survival outcomes and independent response assessment with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma: 42-month follow-up of a randomized phase 3 clinical trial

Motzer, Robert J, Escudier, Bernard, McDermott, David F, ArÃ©n Frontera, Osvaldo, Melichar, Bohuslav, Powles, Thomas, Donskov, Frede, Plimack, Elizabeth R, BarthÃ©lÃ©my, Philippe, Hammers, Hans J, Geo

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2020

File:

PDF, 2.49 MB

2020

31

The Impact of Histological Subtype on the Incidence, Timing, and Patterns of Recurrence in Patients with Renal Cell Carcinoma After SurgeryâResults from RECUR Consortium

Abu-Ghanem, Yasmin, Powles, Thomas, Capitanio, Umberto, Beisland, Christian, JÃ¤rvinen, Petrus, Stewart, Grant D., Gudmundsson, EirÃkur Orri, Lam, Thomas B., Marconi, Lorenzo, FernandÃ©z-Pello, Sergi

Journal:

European Urology Oncology

Year:

2020

File:

PDF, 1.05 MB

2020

32

Does PET imaging have a role in renal cancers after all?

Thomas Powles, Peter J Ell

Journal:

The Lancet Oncology

Year:

2007

Language:

english

File:

PDF, 71 KB

english, 2007

33

A Systematic Review of Neoadjuvant and Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer

Joshua J. Meeks, Joaquim Bellmunt, Bernard H. Bochner, Noel W. Clarke, Siamak Daneshmand, Matthew D. Galsky, Noah M. Hahn, Seth P. Lerner, Malcolm Mason, Thomas Powles, Cora N. Sternberg, Guru Sonpavd

Journal:

European Urology

Year:

2012

Language:

english

File:

PDF, 635 KB

english, 2012

34

Development and validation of an ultra-high performance LC–MS/MS assay for intracellular SN-38 in human solid tumour cell lines: Comparison with a validated HPLC-fluorescence method

Ghazaly, Essam, Perry, Jackie, Kitromilidou, Christiana, Powles, Thomas, Joel, Simon

Journal:

Journal of Chromatography B

Year:

2014

Language:

english

File:

PDF, 823 KB

english, 2014

35

Castration Refractory Prostate Cancer: Cinderella Finally Comes to the Ball

Chowdhury, Simon, Harper, Peter, Powles, Thomas

Journal:

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

36

Venous thromboembolism risk in patients with locoregional urothelial tract tumors

Ramos, Jorge D., Wingate, Jonathan T., Gulati, Roman, Plimack, Elizabeth R., Harshman, Lauren C., Powles, Thomas, Crabb, Simon J., Niegisch, Guenter, Bellmunt, Joaquim, Ladoire, Sylvain, De Giorgi, Ug

Journal:

Clinical Genitourinary Cancer

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

37

Adjuvant Vascular Endothelial Growth Factor–targeted Therapy in Renal Cell Carcinoma: A Systematic Review and Pooled Analysis

Sun, Maxine, Marconi, Lorenzo, Eisen, Tim, Escudier, Bernard, Giles, Rachel H., Haas, Naomi B., Harshman, Lauren C., Quinn, David I., Larkin, James, Pal, Sumanta K., Powles, Thomas, Ryan, Christopher

Journal:

European Urology

Year:

2018

Language:

english

File:

PDF, 1.25 MB

english, 2018

38

Outcomes based on prior therapy in the phase 3 METEOR trial of cabozantinib versus everolimus in advanced renal cell carcinoma

Powles, Thomas, Motzer, Robert J., Escudier, Bernard, Pal, Sumanta, Kollmannsberger, Christian, Pikiel, Joanna, Gurney, Howard, Rha, Sun Young, Park, Se Hoon, Geertsen, Poul F., Gross-Goupil, Marine,

Journal:

British Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 560 KB

english, 2018

39

The Cancer Immunogram as a Framework for Personalized Immunotherapy in Urothelial Cancer

van Dijk, Nick, Funt, Samuel A., Blank, Christian U., Powles, Thomas, Rosenberg, Jonathan E., van der Heijden, Michiel S.

Journal:

European Urology

Year:

2018

Language:

english

File:

PDF, 845 KB

english, 2018

40

Corrigendum re: “Atezolizumab in Platinum-treated Locally Advanced or Metastatic Urothelial Carcinoma: Outcomes by Prior Number of Regimens” [Eur Urol 2018;73:462–8]

Perez-Gracia, Jose Luis, Loriot, Yohann, Rosenberg, Jonathan E., Powles, Thomas, Necchi, Andrea, Hussain, Syed A., Morales-Barrera, Rafael, Retz, Margitta M., Niegisch, Günter, Durán, Ignacio, Théodor

Journal:

European Urology

Year:

2018

Language:

english

File:

PDF, 128 KB

english, 2018

41

Second-line targeted therapies after nivolumab-ipilimumab failure in metastatic renal cell carcinoma

Auvray, Marie, Auclin, Edouard, Barthelemy, Philippe, Bono, Petri, Kellokumpu-Lehtinen, Pirkko, Gross-Goupil, Marine, De Velasco, Guillermo, Powles, Thomas, Mouillet, Guillaume, Vano, Yann-Alexandre,

Journal:

European Journal of Cancer

Year:

2019

Language:

english

File:

PDF, 600 KB

english, 2019

42

Reply to Alessia Cimadamore, Liang Cheng, Marina Scarpelli, et alâs Letter to the Editor re: Alfonso GÃ³mez de LiaÃ±o Lista, Nick van Dijk, Guillermo de Velasco Oria de Rueda, et al. Clinical Outcome After Progressing to Frontline and Second-line AntiâPD-1/PD-L1 in Advanced Urothelial Cancer. Eur Urol 2020;77:269â76. Progression and Hyperprogression Versus Pseudoprogression: Morphologic Documentation

van Dijk, Nick, GÃ³mez de LiaÃ±o Lista, Alfonso, Szabados, Bernadett, Powles, Thomas, van der Heijden, Michiel S.

Journal:

European Urology

Year:

2020

File:

PDF, 144 KB

2020

43

Erythropoietin to treat anaemia in patients with head and neck cancer

Thomas Powles, Jonathan Shamash, Wai Liu

Journal:

Year:

2004

Language:

english

File:

PDF, 54 KB

english, 2004

44

The efficacy and safety of weekly vinorelbine in relapsed malignant pleural mesothelioma

Stebbing, Justin, Powles, Thomas, McPherson, Kirsty, Shamash, Jonathan, Wells, Paula, Sheaff, Michael T., Slater, Sarah, Rudd, Robin M., Fennell, Dean, Steele, Jeremy P.C.

Journal:

Year:

2009

Language:

english

File:

PDF, 161 KB

english, 2009

45

Local treatments for metastases of renal cell carcinoma: a systematic review

Dabestani, Saeed, Marconi, Lorenzo, Hofmann, Fabian, Stewart, Fiona, Lam, Thomas B L, Canfield, Steven E, Staehler, Michael, Powles, Thomas, Ljungberg, Börje, Bex, Axel

Journal:

The Lancet Oncology

Year:

2014

Language:

english

File:

PDF, 333 KB

english, 2014

46

Elevating the Horizon: Emerging Molecular and Genomic Targets in the Treatment of Advanced Urothelial Carcinoma

Kurtoglu, Metin, Davarpanah, Nicole N., Qin, Rui, Powles, Thomas, Rosenberg, Jonathan E., Apolo, Andrea B.

Journal:

Clinical Genitourinary Cancer

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

47

Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma

Powles, Thomas, O'Donnell, Peter H., Massard, Christophe, Arkenau, Hendrik-Tobias, Friedlander, Terence W., Hoimes, Christopher J., Lee, Jae Lyun, Ong, Michael, Sridhar, Srikala S., Vogelzang, Nichola

Journal:

Year:

2017

Language:

english

File:

PDF, 344 KB

english, 2017

48

Long-term follow-up of overall survival for cabozantinib versus everolimus in advanced renal cell carcinoma

Motzer, Robert J., Escudier, Bernard, Powles, Thomas, Scheffold, Christian, Choueiri, Toni K.

Journal:

British Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 404 KB

english, 2018

49

ATLANTIS: a randomised multi-arm phase II biomarker-directed umbrella screening trial of maintenance targeted therapy after chemotherapy in patients with advanced or metastatic urothelial cancer

Fulton, Ben, Jones, Robert, Powles, Thomas, Crabb, Simon, Paul, James, Birtle, Alison, Chowdhury, Simon, Hussain, Syed, Morris, Anna, Soulis, Eileen, Morrison, Paula

Journal:

Year:

2020

File:

PDF, 954 KB

2020

50

Axitinib plus immune checkpoint inhibitor: evidence- and expert-based consensus recommendation for treatment optimisation and management of related adverse events

GrÃ¼nwald, Viktor, Voss, Martin H., Rini, Brian I., Powles, Thomas, Albiges, Laurence, Giles, Rachel H., Jonasch, Eric

Journal:

British Journal of Cancer

Year:

2020

File:

PDF, 492 KB

2020

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